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Artificial Kidney Biography
An additional line of research on renal regeneration focuses on development of living membranes for an intradialytic biological kidney support device. End-stage renal disease patients have uremic complications that result in high cardiovascular morbidity and a poor quality of life, despite hemodialysis. Uremia is caused by the retention of a large group of molecules with different physical and chemical properties that are not sufficiently cleared by hemodialysis. Within REFORM, a cell device (BioKid) will be developed capable of effective clearance of these toxins ex vivo. The BioKid will comprise of multiple so-called living membranes, i.e. tight monolayers of human renal epithelial cells that are grown on newly designed semi-permeable bioactive polymer membranes. A unique supramolecular approach will be used to develop a 2D bioactive polymer membrane that regulates long-lived monolayer integrity and cell viability under uremic conditions. The expertise and knowledge gained on the supramolecular 2D bioactive polymer membrane will be translated into a 3D configuration that will be applied in a simple in vitro set-up as a cell-aided intradialytic uremic toxin removal device. This will serve as a proof of principle for a more sophisticated device that can be used in the future to treat uremic symptoms in end-stage renal disease patients on dialysis.
Artificial Kidney Biography
An additional line of research on renal regeneration focuses on development of living membranes for an intradialytic biological kidney support device. End-stage renal disease patients have uremic complications that result in high cardiovascular morbidity and a poor quality of life, despite hemodialysis. Uremia is caused by the retention of a large group of molecules with different physical and chemical properties that are not sufficiently cleared by hemodialysis. Within REFORM, a cell device (BioKid) will be developed capable of effective clearance of these toxins ex vivo. The BioKid will comprise of multiple so-called living membranes, i.e. tight monolayers of human renal epithelial cells that are grown on newly designed semi-permeable bioactive polymer membranes. A unique supramolecular approach will be used to develop a 2D bioactive polymer membrane that regulates long-lived monolayer integrity and cell viability under uremic conditions. The expertise and knowledge gained on the supramolecular 2D bioactive polymer membrane will be translated into a 3D configuration that will be applied in a simple in vitro set-up as a cell-aided intradialytic uremic toxin removal device. This will serve as a proof of principle for a more sophisticated device that can be used in the future to treat uremic symptoms in end-stage renal disease patients on dialysis.
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