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Friday, 11 January 2013

Cancer Of The Throat And Larynx

Source(google.com.pk)
Cancer Of The Throat And Larynx Biography
Cancer in the throat occurs in the passages from the neck to the rest of the body. This includes the voice box, or larynx, and the areas behind the oral cavity, known as the pharynx.
What is going on in the body?

The throat is exposed to every substance a person takes into the body whether by breathing, drinking, or eating. Some of these substances, especially tobacco, can cause severe damage to the cells lining the throat. Damage over time may cause cells to undergo changes that lead to cancer. The person may have more than one cancer develop at a time in this area because the damage affects the whole area. After a cell becomes cancerous, it will begin to grow and divide uncontrollably. The cancer cells will then form a tumor. The tumor spreads by invading the tissue around it. Some of the cancer cells will enter the system that drains fluids into lymph nodes in the neck. The lymph nodes filter the blood and help fight infections. When a cancer cell enters a lymph node, it may also be filtered out, and form a new tumor in the node.

Cancerous cells from the tumor can also break off from the tumor and enter the blood stream. These cells will go to other parts of the body and develop into new tumors. The cancer will spread, or metastasize, through the body if not successfully treated. The cancer causes death from damage to vital organs.

What Are The Causes And Risks of The Disease?
People who use tobacco products and also drink beverages containing alcohol are at great risk for developing these cancers as well as cancers in the mouth. Alcohol consumption tends to accelerate the damage caused by tobacco.
Symptoms & Signs

What Are The Signs And Symptoms Of The Disease?
Symptoms depend on where the cancer is located. Cancers at the base of the tongue will cause throat pain and difficulty swallowing. Cancers on the voice box or larynx will cause hoarseness by pressing on the vocal cords.
Diagnosis & Tests

How is The Disease Diagnosed?
When a tumor is found, a small piece of it must be removed with a biopsy, to determine if it is cancerous. Surgery is usually performed to remove the rest of the tumor, known as resection, and to determine the extent of the disease. It is likely that a large tumor might have spread to local lymph nodes by the time of diagnosis. Nearby lymph nodes will be removed at the time of surgery to determine this. Other tests such as CT scans of the chest and neck may be performed to investigate potential spread to distant sites. Understanding the extent of the disease will guide the choices of therapy.
Prevention & Expectations

What Can Be Done Preto Vent The Disease?
Avoiding all tobacco products is the most important health behavior in preventing these and other cancers. Limiting alcohol consumption is also helpful. Smokers who drink heavily have a risk for throat cancer up to 15 times greater than those who do not drink or smoke. A person who is at risk for these cancers from lifestyle choices should alert a healthcare provider when any hoarseness, pain in the throat, or difficulty swallowing develops. Early detection will help ensure successful treatment. These cancers are easier to treat when small.

Quitting smoking is the single most important action a person can do to improve overall health status. There are many methods to help people quit smoking. Healthcare providers can make referrals and offer advice on how to quit smoking.
What are the long-term effects of the disease?

Cancer of the throat and larynx are fatal if not successfully treated.

What Are The Risks To Others?
There is no risk to others.
Treatment & Monitoring

What Are The Treatments For The Disease?
Surgery to remove the tumor and tissue around it is the primary treatment. If it is suspected that lymph nodes are involved, then nearby lymph nodes in the neck will be removed. Radiation therapy may be applied to the area of surgery later to improve the likelihood that all of the cancer has been destroyed. Sometimes a very small tumor is found on the vocal cords. At that stage it has not spread. In this rare instance, surgery may be avoided by directing radiation at the tumor. Treatment for this type of cancer that has spread to other parts of the body is directed at improving quality of life. It is not curable in the advanced stages. Chemotherapy may be given to reduce the size of the tumors. Radiation may be given to areas of local pain.

What Are The Side Effects For The Treatments?
Extensive surgery on the throat will have long-term consequences. If the larynx has to be removed, the person will be unable to talk and will have a tracheostomy, or permanent breathing tube in the neck. A special device can be placed that will aid speech, but it will not be normal speech. Surgery on the neck will also change the contour of the neck. Reconstruction at the time of surgery may improve this.

The effects of radiation are temporary and resolve after treatment. The more troublesome side effects include dry mouth, sores developing in the mouth and throat, and fatigue.

Sometimes chemotherapy is given during radiation to make the radiation work better. In this case, the effects of the radiation may be stronger. When given to control advanced disease, the medications are chosen to improve quality of life. Most side effects such as nausea can be easily managed.

What Happens After Treatment For The Disease?
After treatment of early stage disease, the person will need to be followed closely. It is possible new cancers may form or that the previously treated cancer can recur. In advanced stage disease, the person will be followed to determine response. The disease is likely to progress over time.

How is The Disease Monitored?
The affected area will need to be observed at intervals for signs of recurrence. CT scans and other specialized x-rays will be performed if a person develops a symptom indicating the cancer has come back or spread to another site in the body. The need for close monitoring will continue throughout the person’s lifetime, even for those with small cancers.
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx
Cancer Of The Throat And Larynx

Cancer Of The Throat

Source(google.com.pk)
Cancer Of The Throat Biography
Throat cancer is a general term that applies to cancer that develops in the throat (pharyngeal cancer) or in the voice box (laryngeal cancer). The two cancers are often linked together due to fact that the voice box is located directly below the throat. Within the voice box and throat there are more specific types of cancer. Nasopharyngeal cancer is cancer that begins in the nasopharynx or the part of the throat located just behind the nose. Oropharyngeal cancer begins in a part of the throat right behind your mouth, that includes the tonils. Hypopharyngeal cancer begins in the lower part of your throat just above your esophagus and windpipe. Glottic cancer is cancer of the vocal chords. Lastly supraglottic cancer and subgottic cancer begin in the upper (spraglottic) and lower portion (subglottic) of your voice box. Each of the separate types has a link to its own symptoms, some of which include a cough, change in voice, difficulty swallowing, ear pain, sore throat, unintentional weightless, or a lump or sore that doesn’t heal.

Throat cancer occurs when cells in your throat develop genetic mutations, causing cells to grown uncontrollably and continue living after healthier cells would normally die. What causes the mutations is generally unknown but risk factors show a link to carcinogens like alcohol and tobacco.

Carcinogenesis is literally the creation of cancer. Proto-oncongenes are genes that promote cell growth and mitosis. Tumor suppressor genes discourage cell growth or temporarily halt cell decision to carry out DNA repair. What a mutation is to occur in a proto-oncogene (becomes oncogene) damage would be suppressed by normal mitosis control and tumor suppressor genes. One mutation tumor suppresses would not cause caner either because of many backup genes that duplicate it’s functions. Only when enough proto-oncogenes have been mutated into oncogenese and enough tumor suppressor genes are deactivated or damaged signals for cell growth overwhelm the signals to regulate it and cell growth quickly spirals out of control.

One’s risk of throat cancer increases if they smoke or drink alcohol. People who use tobacco and alcohol together are at more of risk then those who use them separately. Some research also suggests that leukoplakia (white patches in mouth) or erythorkplakia (red raised patches in the mouth) may also be throat cancer risk factors. Most throat cancers develop in adults older then 50 and men are ten times more likely the women. Ethnicity may also be a factor with African American men in the U.S. being found to be at a 50% higher risk of throat cancer than Caucasian men.

When it comes to diagnosing throat cancer doctors have several different options. Doctors may use a special lighted scope (endoscope) to get a closer look at throat during a procedure called an endoscopy. And Laryngoscope is another type of scope that can be inserted in your voice box. If abnormalities are found you can pass a surgical instrument through the scope to collect a tissue sample (biopsy). Imaging tests, including X-ray, computerized tomography scans, magnetic resonance imaging, and positron emission tomography may help doctors determine the extent of your cancer beyond the surface of your throat or voice box. Once diagnosed, the next step is to determine the extent or stage of the cancer. Stages help to determine treatment options per patient. Stages are characterized by roman numerals I- IV and each subtype ahs its own criteria for each stage.

Treatment options are then based on many factors: location and stage of throat cancer, type of cells involved, overall heath, and personal preference. Radiation therapy uses high-energy particles like X-rays to deliver radiation to the cancer cells causing them to die. Another option is surgery. Depending on the stage or type of cancer the procedures vary. For cancer that is confined to the surface of the throat or the vocal chords may be treated surgically using endoscopes. For serious cases of throat cancer there are procedure to remove all or part of ones throat or voice box. Other options include: chemotherapy, uses chemicals to kill cancer cells, and targeted drug therapy, which treats throat cancer by altering specific aspects of cancer cells that fuel their growth.

Rehabilitation after treatment for throat cancer is tough. Treatment often causes compilations that may require working with specialists to regain the ability swallow, eat solid foods, and talk. This terrible disease is one that I would wish on nobody, and hopefully one day we will find the cure.
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Cancer Of The Throat
Cancer Of The Throat
Cancer Of The Throat
Cancer Of The Throat
Cancer Of The Throat
Cancer Of The Throat



Treatment For Breast Cancer

Source(google.com.pk)
Treatment For Breast Cancer Biography
Biological therapy uses the body's own immune system (its antibodies) to fight breast cancer cells, while leaving healthy cells unaffected.

One such antibody is Herceptin, a monoclonal (meaning single) antibody. An antibody is a protein made by the body's own immune system. But Herceptin can work only if the woman carries the HER2 gene in those tumor cells. About 25% of breast cancer patients carry this gene and are considered HER2 positive.

Herceptin is the first-line treatment of HER2-positive metastatic breast cancer in combination with chemotherapy drugs. Herceptin may also be used alone, indefinitely for HER2- positive metastatic breast cancer.

Perjeta (pertuzumab) is another monoclonal antibody approved for treatment of HER2-positive metastatic breast cancer. It is approved for use in combination with Herceptin and the chemotherapy Taxotere.

Another drug of this type is Tykerb. It works in HER2-positive patients when Herceptin is no longer effective. It is used in combination with Xeloda, Femara, or Herceptin.

Other types of antibodies are being researched to fight cancer and include:

Angiogenesis Inhibitors.
 These antibodies prevent the growth of new blood vessels, cutting off the supply of oxygen and nutrients to cancer cells. However, the only such drug used for breast cancer, bevacizumab, lost its FDA approval for breast cancer because the drug's risks outweighed its benefits and it didn't improve the overall survival of breast cancer patients.

Signal Transduction Inhibitors.
These antibodies block signals inside the cancer cell that helps the cells divide, stopping the cancer from growing. They are currently being studied to see if they're effective.
Before treatment begins, print out these Questions to Ask to help you better understand your care.

Also see, Follow-Up Care After Your Treatment.

Side Effects of Biological Therapy for Breast Cancer
When biological therapy is used to treat breast cancer, side effects can include:

Allergic reactions
Difficulty breathing
Swelling
Nausea
Fever and chills
Dizziness or weakness
Talk to your doctor about the possible side effects to watch for and what you should do if they occur. The FDA has warned that the treatment with Perjeta may be harmful or fatal to a fetus. Women who are pregnant should not take Perjeta.

Recognizing a Breast Cancer Emergency
If you develop fever and chills, notify your doctor immediately or go to the emergency room. Other symptoms to tell your health care provider about include:

New mouth sores, patches, swollen tongue, or bleeding gums.
Dry, burning, scratchy, or "swollen" throat.
Cough that is new or persistent and produces mucus.
Changes in bladder function, including increased frequency or urgency to go; burning during urination; or blood in your urine.
Changes in gastrointestinal function, including heartburn; nausea, vomiting, constipation, or diarrhea that lasts longer than two or three days; or blood in stools.

Biological therapy for breast cancer takes advantage of the body's own immune or hormonal system to act on cancer cells - while leaving healthy cells relatively intact. This approach is designed to minimize the side effects associated with traditional treatments like chemotherapy.

One strategy is to use antibodies to attack cancer cells or block their activities. An antibody is a protein that can attach to specific proteins in the body, called antigens. Antibodies can be natural, made by one's own immune system, or made artificially. One example of a manufactured antibody is Herceptin.

Herceptin is believed to act in three ways to stop cancer cells from growing quickly and out of control:

It sticks to special receptors on the cancer cells, stopping them from growing.
It signals the body's own natural killer cells to attack the cancer cells.
It can work with chemotherapy medications, stopping cancer cells damaged by chemo from repairing themselves.
But Herceptin can work only if the woman carries the HER-2 gene in those tumor cells. About 25% of breast cancer patients carry this gene. (They are considered HER-2 positive). It currently is the first-line treatment of HER-2-positive metastatic breast cancer used in combination with one of the drugs known as taxanes (Taxotere, Taxol, and Abraxane).

Another form of biological therapy is the use of drugs composed of small molecules that interrupt the hormonal or chemical pathways that cancer cells need to grow. Tykerb is an example of a small molecule that is used in combination with chemotherapy to treat some advanced cases of breast cancer.

One disadvantage of antibody treatment is that it is generally only available by injection. Small molecule treatment can be taken in pill form.

A third drug, Perjeta, has recently been approved by the FDA to treat HER-2-positive metastatic breast cancer used in combination with Herceptin and Taxotere.

Other types of antibodies and small molecules that are being researched to fight breast cancer include:

Angiogenesis inhibitors. These antibodies prevent the growth of new blood vessels, cutting off the supply of oxygen and nutrients to cancer cells. Avastin, which had been used to treat breast cancer, is no longer approved by the FDA because the risks outweigh the benefits.
Signal transduction inhibitors. These antibodies block signals inside the cancer cell that helps the cells divide, stopping the cancer from growing.

Side Effects of Biological Therapy
Side effects of biological therapy can include allergic reactions, difficulty breathing, swelling, nausea, fever or chills, and dizziness or weakness. Talk to your doctor about the possible side effects to watch for.

Recognizing a Cancer Emergency
Call your nurse or doctor about your cancer if you have:

A temperature greater than 100.4 degrees Fahrenheit. If you experience any fever and chills, notify your doctor immediately. If you are unable to contact your doctor, go to the emergency room.
New mouth sores or patches, a swollen tongue, or bleeding gums
A dry, burning, scratchy, or "swollen" throat
A cough that is new or persistent and produces mucus
Changes in bladder function, including increased frequency or urgency to go, burning during urination, or blood in your urine
Changes in gastrointestinal function, including heartburn, nausea, vomiting, constipation, or diarrhea that lasts longer than two or three days
 Blood in stools
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer
Treatment For Breast Cancer

Treatment For Breast Cancer
Treatment For Breast Cancer

Thursday, 10 January 2013

What Are Symptoms Of Oral Cancer

Source(google.com.pk)
What Are Symptoms Of Oral Cancer Biography
Mouth cancer, also known as oral cancer, is a type of cancer in which malignant cells start developing inside the tissues lining the mouth. This type of cancer can be cured if it is diagnosed and treated on time. The risk factors and causes of oral cancer are-

Smoking and drinking alcohol- Smoking any form of tobacco – cigarettes, pipes or cigars – and excessive alcohol consumption are the major risk factors for mouth cancer. Smokers are at a higher than average risk of getting oral cancer, Mouth cancer also occurs in people who have never drunk or smoked, but this is uncommon.

Diet- An improper diet may increase the risk of mouth cancer due to a lack of zinc or other vitamins and minerals. A diet high in fresh fruit and vegetables seems to reduce the risk of developing cancer of the mouth. A diet rich in fresh fruits and vegetables is known to decrease the risk of getting mouth cancer.

Low immunity- People who are having a reduced immunity due to HIV or AIDS are at a greater risk of developing mouth cancer. Taking medicines for suppressing immunity after organ transplantations also increases the risk of mouth cancer.

Previous history of cancer- People who have suffered from mouth cancer earlier have an increased risk of getting it for the second time. Women have a higher risk of getting mouth cancer for the second time. People who have had some other types of cancer also have an increased risk of oral cancer.

The common symptoms of mouth cancer are:-

Ongoing pain or discomfort inside the mouth- This is one of the commonest symptoms of mouth cancer.

Mouth ulcers- Mouth ulcers which are not healing easily are also a common symptom of mouth cancer. 80% people with mouth cancer have this symptom (80%) have a mouth ulcer that does not heal.

Difficulty in swallowing- Pain or a burning sensation while chewing and swallowing food is a symptom of mouth cancer. The patient may even feel that the food is sticking in his throat after swallowing.

Speech problems- Mouth cancer can affect the voice. The voice may become quieter or husky.

A lump in the neck- This may be caused by an enlarged lymph node because of the cancer.

Weight loss- It is a common symptom of many cancers. Extreme weight loss may be a sign of advanced cancer.
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer
What Are Symptoms Of Oral Cancer

Oral Mouth Cancer

Source(google.com.pk)
Oral Mouth Cancer Biography
Abstract—One of the major problems related to cancer treatment is its recurrence. Without knowing in advance how likely
the cancer will relapse, clinical practice usually recommends
adjuvant treatments that have strong side-effects. A way to
optimize treatments is to predict the recurrence probability by
analysing a set of bio-markers. The NeoMark European project
has identified a set of preliminary bio-markers for the case of
oral cancer by collecting a large series of data from genomic,
imaging and clinical evidences. This heterogeneous set of data
needs a proper representation in order to be stored, computed
and communicated efficiently. Ontologies are often considered the
proper mean to integrate biomedical data, for their high level of
formality and for the need of interoperable, universally accepted,
models. This paper presents the NeoMark system and how an
ontology has been designed to integrate all its heterogeneous data.
The system has been validated in a pilot which data will populate
the ontology and will be made public for further research.
Index Terms—Cancer, Genetic expression, Computer aided
diagnosis, Biomedical image processing
I. INTRODUCTION
Cancer is the second cause of death in western countries.
Although current treatments can be effective, the main problem of cancer is its recurrence either locally or by distant
metastases, which are difficult to predict and prevent. The Oral
Squamous Cell Carcinoma (OSCC), focus of this research,
accounts for the 5% of all cancers, and has a rate of 25
to 50% of recurrence in 5 years, 90% of which within two
years from surgery [1]. In order to avoid relapses, adjuvant
chemo or radio-therapy treatments are usually administered
to all patients during follow-up, even in absence of disease
signs. These treatments are heavy and have strong side-effects
that may harm also patients who are in fact already completely
recovered. Knowing in advance which patients have the higher
risk of disease recurrence, would help to initiate adjuvant treatments only in a limited, high-risk subgroup. In addition, the
early identification of a neoplastic recurrence during follow-up
would allow starting an appropriate treatment in time.
D.Salvi, M.T. Arredondo and M.F. Cabrera are with Life Supporting Technologies, Universidad Politecnica
The most classical method to predict OSCC recurrence is
the TNM staging, which is based mainly on the dimensional
characteristics of the tumour and on the presence, number and
site of neck nodes metastasis. Unfortunately, its inadequacy
is today recognised because of the uncertain behaviour of
squamous cancer, which can be sometimes very aggressive
and others can metastasize slowly after surgery [2]. This
uncertainty in progression has led researchers to seek a
larger number of markers. Many clinical, histopathological,
radiological and genetic factors were studied, but none of the
different groups taken, distinctly provides clinically applicable
markers of tumour aggressiveness [3]. Given the multi-level
nature of cancer (genes, cells, tissues, organs) integration of
the different groups of data is required. Whereas different
reports are present in literature on data integration and creation
of standardized prognostic algorithms for bladder and breast
cancer, nothing is available for head and neck cancer. To cover
this lack, the NeoMark project was created.
NeoMark [4] is an European co-funded research project
which aimed at identifying the optimal set of patient-specific
and disease-specific bio-markers with a high predictive power
for the case of OSCC cancer.
The NeoMark strategy is designed to be integrated into
normal staging and follow-up protocols. Patients are assessed
before treatment and, at the time of remission, a wide range
of data is collected including clinical observations, radiologic
and genomic data. A set of relevant markers expressed only in
presence of the disease is then selected and relapse probability
is estimated. If the same set of bio-markers appears during
post-remission follow-up, it would show a high probability of
relapse, advising early intervention.
This strategy is supported by an Information and Communications Technology (ICT) based system which allows
physicians to:
administer patients
upload clinical data including histological information,
surgery evidence, and risk factors
analyse jointly multiple images from MR/CT scans
analyse gene expressions by means of micro-arrays and
a mobile PCR system
receive indicators of the probability of relapse for supporting the clinical decision during the follow-up
download anonymised data for further research and statistics
The following sections describe the details of the NeoMark
system, how an ontology for integrating all the data collected
in the system has been designed, some results of the pilot we

Oral Mouth Cancer
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