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Thursday, 10 January 2013

Mouth Ulcers

Source(google.com.pk)
Mouth Ulcers Biography
Magic mouthwash is the term given to a solution used to treat mouth sores (oral mucositis). Oral mucositis can be extremely painful and can result in an inability to eat, speak or swallow. Magic mouthwash may be used to treat mouth sores that result from some forms of chemotherapy and radiation therapy.

There are several versions of magic mouthwash. Some are available pre-mixed (First-Mouthwash BLM, First-BXN Mouthwash, others), while others are prepared to order by pharmacists. If it's determined that magic mouthwash might be helpful, your doctor will likely write a prescription listing the ingredients and the amount of each. Magic mouthwash usually contains at least three of these basic ingredients:

An antibiotic to kill bacteria around the sore
An antihistamine or local anesthetic to reduce pain and discomfort
An antifungal to reduce fungal growth
A corticosteroid to treat inflammation
An antacid to enhance coating of the other ingredients inside the mouth
Most formulations of magic mouthwash are intended to be used every four to six hours, and to be held in your mouth for one to two minutes before being either spit out or swallowed. It's recommended that you don't eat or drink for 30 minutes after using magic mouthwash so that the medicine has time to produce an effect.

It's unclear how effective magic mouthwash is in treating oral mucositis. That's because of the lack of standardization in the formulations of mouthwash, and poorly designed studies done to gather data. If you have mouth sores that cause you pain and discomfort, talk with your doctor.

Side effects of magic mouthwash may include problems with taste, a burning or tingling sensation in the mouth, drowsiness, constipation, diarrhea, and nausea.
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Cancer Of The Mouth

Source(google.com.pk)
Cancer Of The Mouth Biography
IBC Hospital’s general treatment approach is based on these concepts:

1. The uniquely individual biochemistry of the patient.

2. The development of treatment programs (protocols) taking this unique individualized biochemistry into account.

3. A multifactorial, integrative, succesive, restorative approach aiming at:
Detoxification and dietary adjustment.
Balancing of the neuro-endocrinological (hormonal) systems.
Regulation and restoration of the various components of the immune defense system.
An all-out attack on pathogens with the fullest possible range of modalities with an emphasis on natural, non-toxic methods.
Exhaustive review of dental health to ensure the absence of infectious foci and the presence of mercury amalgams and other potentially toxic materials.
Fostering of a healing psychological milieu.

IBC Hospital is aware that no two patients are exactly alike, so that no two treatments (in application or response) are exactly alike. We are interested not in treating a disease per se but in helping our patient heal him/herself.

Integrative diagnostics and clinical applications are bringing about long-term survivals and many cases of complete success in advanced disease conditions around the world.

IBC Hospital is the home of many breakthrough therapies that were researched and developed to safe and effective levels never before achieved.

The IBC staff notes that its maximum effort is aimed at restoring wellness and controling most of the metabolic conditions we have treated in thousands of patients from some two dozen countries over a quarter century.

Service to International Patients
With a professional bilingual staff at all levels, from medical to nursing, from administrative to transportation, we all strive to create a caring and nurturing environment for the patient. IBC Hospital has accumulated for over 25 years the experience and know-how to implement and successfully manage one of the major integrative health centers in the world.
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Cancer Of The Mouth

Tongue Cancer

Source(google.com.pk)
Tongue Cancer Biography

Alinea's version of pheasant, served with shallot, cider gel and burning oak leaves.

Lara Kastner/Alinea
A typical 23-course meal at Chicago's Alinea restaurant might include olive oil lollypops, sweet potatoes skewered by smoking cinnamon sticks, strips of bacon hanging from a stainless steel bow, and pheasant tempura-fried with apple cider, impaled on a flaming oak leaf.

Alinea, which opened in 2005, was named the best restaurant in America by Gourmet Magazine in 2006. The restaurant's co-founder and head chef, Grant Achatz, is one of the leading members of the molecular gastronomy movement, which uses unexpected flavor combinations and exotic laboratory tools to create foods based on the molecular compatibility of ingredients.

"What makes the food that we do at Alinea so interesting on the outside is that we really don't let ourselves say no to an idea," Achatz says. "When we start looking at things really critically or even very simply, we realize that there's more than one way to actually get the same results ... You're deconstructing the components of a course and putting them back together."

Web Resources

Alinea Restaurant
Peter Sagal: On Visiting Alinea
Playing with unexpected flavors and scents plays a big part in Achatz's kitchen. Some of Alinea's dishes are served alongside a pillow case with tiny holes in it, designed to release certain fragrances while diners eat.

"We've done firewood ashes, we've done leather, we've done grass," says Achatz. "There's a lot of smells that you can't necessarily consume. You're not going to go out and chew on a baseball glove. But, in a lot of ways, a lot of smells that aren't necessarily edible smell good, and they remind you of certain aspects of food. So making those associations with what smells good or smells a certain way and pairing that with actual edible ingredients is one avenue that we take creatively."

In 2007, Achatz lost his own ability to taste. He was diagnosed with stage 4 tongue cancer, which metastasized to both sides of his neck. His surgeons told him they were going to cut out his tongue and replace it with muscle from another part of his body. With the surgery, Achatz only had a 50 percent chance of surviving beyond two years. But, he says, he was even more afraid of losing his ability to taste and eat.


Gotham
Life, on the Line: A Chef's Story of Chasing Greatness, Facing Death, and Redefining the Way We Eat
By Grant Achatz
Hardcover, 400 pages
Gotham
List price: $27.50
Read An Excerpt
"I lived my whole life in the kitchen," he says. "Not only that, but it's the passion, it's the love for cooking and food. It's dictated my entire life — every aspect of it. So, in some ways, the thought of not being able to do that anymore radically affects your life."

Achatz found a clinical trial at the University of Chicago that agreed to treat him with radiation and chemotherapy. The radiation treatments burned his tongue, shed the lining of his esophagus — and completely destroyed his taste buds.

"It was very strange to not be able to discern any flavor at all," he says. "It's funny because, clearly, you know you have to eat to live. But even knowing that, for me, there was no reason to eat. I had no interest in eating whatsoever. I would put something in my mouth — say a vanilla milkshake — and it tasted like nothing."

Achatz's cancer is now in remission. After his treatment ended, his ability to taste came back — but slowly. His perception of different flavor combinations — sweet, salty, bitter — came back one flavor at a time.

"I started from zero, and the first thing back was sweet," he says. "So my palate developed just as a newborn — but I was 32 years old. So I could understand how flavors were coming back and how they synergized together. ... It was very educational for me. I don't recommend it, but I think it made me a better chef because now I really understand how flavor works."

Achatz was named Best Chef in America in 2008 by the James Beard Foundation. He is the author of two books, the memoir Life, on the Line and the coffee table-style cookbook Alinea. He plans to open a new restaurant in Chicago. Called Next, it will completely change its food and style every few months — allowing Achatz to experiment with different ethnic cuisines and periods in time.

On Intimidating Dishes

"Some of the courses served at Alinea are meant to intimidate because, if you think about eating, we do it two, three, four times a day since we're born, basically. And the act of eating — the mechanics of eating — become very monotonous. So literally you're either picking up a fork, a spoon, and you're eating from a plate or bowl with the same motion every time. So if we can break that monotony, then we get you to take notice of the moment, and now you're thinking about the food. It's making you feel a certain way. Then we've won."

On slowing people down so they taste their food


"Alinea is not the type of restaurant where you go if you're in a hurry. Really, it's about enjoying that three-hour block of time and reflecting on the food, having great conversation with your dining companion. Nobody really needs to eat like that. You need to eat to live. But you certainly don't need to sit down and have a 200-hour, 23-course meal. It's entertainment. It's about having a great time, processing it, thinking about it. We like to think that the food is, in a lot of ways, an intellectual exercise. Sitting through a three-hour meal and having all these feelings — whether they be about the actual food or whatever the occasion is or who you're eating with — [it's] kind of checking yourself out of the pace of life for three hours and enjoying yourself."

On his "Frankenstein-like" anti-griddle


"It allows us to freeze things that normally don't freeze. For instance, if you take a cup full of olive oil and put it in your freezer at home overnight, you're going to wake up the next morning and it's still going to be liquid because the freezing point of olive oil is very, very low. You take a tablespoon of that olive oil and you put it on top of the anti-griddle, and it will instantly freeze. We've made olive oil lollipops, and it was savory and kind of floods the palate with this smoky paprika and roasted red pepper oil."

On playing with flavor


"If I present to you something that I call 'root beer float,' but it's not in a glass — it's on a plate — it's not liquid — it's solid — and it's not brown — it's completely clear — and I say 'root beer float,' and you look at it and you look at me and you think I'm crazy, I think that's a good thing, because now you're engaged. We're engaging you on so many different levels. And then the payoff is when you put that perfectly clear bite-size cube in your mouth, it tastes like a root beer float."


Excerpt: 'Life On The Line'

TRY OUT AT THE LAUNDRY


I entered the French Laundry kitchen and saw a tall lanky man sweeping the floor. His back was toward me and he didn't hear me enter, so he kept doing his job for a few seconds. I peered past him looking for chef Keller, waited a few seconds for the sweeper to notice me, and when he didn't, approached him. "I'm Grant Achatz, here for a tryout. Is chef Keller in?"

"Yeah. That's me," he said, letting out a laugh. "You're early, Grant."

He stuck out his hand and shook mine vigorously with an exaggerated up and down motion.

I thought to myself, "Holy shit. He's the first one here, and he's sweeping the floor. What kind of restaurant is this?"

"I'm going to set you up with Kevin. He's in the back putting away produce, but he can show you around and get you started."

"Yes, Chef." My tryout had begun.

"We're going to cut some brunoise. You okay with a knife?"

Kevin demonstrated the tiny dice, pushed the pieces over to the far corner of my board and said, "Leave those there for a reference."

I began cutting the turnip, carrot, and green leek tops into the miniature cubes at a good clip. Another cook approached my cutting board, looked at my work, then back at me. He spoke very slowly, making sure the others around us heard him. "Hi. I'm Josh."

"Grant is from Trotter's," Kevin spoke up on my behalf.

Josh immediately looked down at my board, poked his finger into a pile of my carrot brunoise and pulled out a single piece from the hundred that was cut on a slight angle to form an inconsequentially uneven cube.

"Kevin, you had better watch this guy. His knife skills aren't so good." Josh looked me in the eye and said, "You might want to start over." He slowly walked away.

As we finished up the brunoise, Kevin headed over to chef Keller, who was busy cleaning foie gras for torchon, and inquired what he should have me do next. "Have him peel and slice tomatoes for Eric," he said.

Eric Ziebold was manning the garde manger station, working on the components for a sliced tomato salad. We exchanged introductions and he instructed me to blanch, peel, and slice the Early Girl tomatoes using a deli meat slicer.

I made quick work of peeling them and headed to the slicer.

With every stroke across the slicer the tomato juice would run down toward the bottom of the blade then violently spray at me. I sliced thirty tomatoes, seasoned each layer with minced shallots, olive oil, sel gris, and black pepper, then meticulously stacked them back together so that they would appear to be a whole tomato. In the process, I looked like an ax murderer, my chef coat covered with tomato-juice splatter.

Chef Keller walked by, looked me up and down, and deadpanned with a wry smile, "Hey. Next time why don't you try to get a little more tomato all over yourself?" He paused a few beats for effect and smiled again. "Go change your coat."

I couldn't help but smile, even though I was embarrassed.

This place felt different. It felt good.
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Tongue Cancer

Mouth Ulcer

Source(google.com.pk)
Mouth Ulcer Biography


Mouth Ulcers or Aphthous Ulcers are lesions caused in the mucous membrane of the mouth and lips. They are caused due to a break in the epithelium of the oral cavity.

They could be located anywhere inside the mouth, under the tongue or at the base of the gums.

They develop due to various reasons, like trauma, infection, drugs, deficiencies or any medical condition.

They can be very painful and can make eating and talking difficult.

They cause a lot of swelling in the surrounding soft tissue, and need to be taken care of, in order to prevent secondary infection.

Mouth Ulcers can develop at any age, but are more commonly seen with advancing age. They are more common in women.

Allopathic  treatments for Mouth Ulcers  include Topical Pain Relieving Creams like Orabase and Lidex , Mouth Rinses containing mild amounts of steroids and Nutritional Supplements containing Vitamin B12.

However these Allopathic treatments do not  cure Mouth Ulcers . They are merely a way of suppressing symptoms.
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Mouth Ulcers Causes

1) Trauma: This is the most common cause of mouth ulcers. Physical trauma could be caused by a sharp tooth-edge, accidental biting, post dental-treatment, or due to dentures.

Trauma can be due to chemical reasons, like alcohol or any irritant that comes in contact with the oral mucosa.

2) Dietary Deficiencies: Deficiency of Vitamin B12 and Zinc in the daily diet has been linked with the development of aphthous ulcers in the mouth.

Deficiency of Vitamin C further aggravates the condition, by causing a delay in the healing process.

3) Viral infections like herpes cause mouth ulcers, which are preceded by blisters that rupture to form ulcers.

4) Helicobacter pylori, the bacteria which causes peptic ulcers can also cause mouth ulcers.

5) Faulty functioning of the immune system can cause the body to attack normal cells and cause ulcers.

6) Recurrent ulcers in the mouth can be due to low levels of immunity.

7) Celiac disease is a common cause of mouth ulcers. Here, the ulcers form due to gluten sensitivity.

8) Hormonal imbalances during menses and pregnancy can also cause mouth ulcers.

9) Emotional stress is also a common finding in individuals with mouth ulcers.

Signs and Symptoms of Mouth Ulcers

Mouth ulcers are red in color with a white or yellow center. They may be present anywhere in the oral cavity, on the tongue, or at the base of the gums.

They may be asymptomatic and noticed on examination of the oral cavity.
They can give rise to a tingling and itchy sensation in the mouth.
Some ulcers are very painful, making eating and talking difficult.
At times, tiny ulcers merge to form one large ulcer, which takes very long to heal.

Mouth ulcers may also give rise to mild fever and swollen lymph nodes in the cervical region.

Diagnosis of Mouth Ulcers

Diagnosis can be easily made by visual examination of the oral cavity.

A detailed history may be required to find out the underlying cause.

Mouth Ulcers Treatment

Conventional Therapy

Symptomatic treatment is the key in curing ulcers. The underlying cause, if known, also needs to be treated. Oral hygiene needs to be maintained to prevent recurrence.

The various treatment options employed are:

-- Topical Pain Relieving Creams like Orabase and Lidex reduce the pain and promote healing.
-- Mouth Rinses containing mild amounts of steroids reduce the swelling and pain.
-- Nutritional Supplements containing Vitamin B12 and folic acid are prescribed when ulcers are caused due to deficiencies.
-- Antacids used for gastritis may help in relieving the burning caused due to mouth ulcers.
-- Extremely hot and spicy food should be avoided completely.

If ulcers don't heal despite all the above measures, they require medical attention.

Biogetica Therapy

Biogetica's natural remedies not only relieve your symptoms and quickly heal your mouth ulcers, but also correct imbalances that cause you to be prone to mouth ulcers.* The advanced Homeopathy and Nutritional remedies in the mouth ulcers kit work specifically by:

• Providing you with quick relief from the acute pain and swelling caused due to ulceration of the oral mucosa*

• Addressing the nutritional deficiencies that are a common cause of aphthous ulcers*

Customers report a marked reduction in relapses of ulcers after taking our products.*


GUAVA LEAVES (Amrud ke Patte) and their health benefits are known to people across the world from ancient times. They are obtained from the guava tree which is
commonly planted in the backyard of the North Asian, Central American, Northern South American and Mexican regions. When its fully grown, it attains the height of around 25 feet, which is very rare.Some studies suggest that guava is better than oranges as it contains more vitamin C. So, its leaves are also extremely beneficial. They lower the blood sugar levels or diabetes. Their use removes the toxins that cause diarrhea.Now, the question arises, how to make use of Guava Leaves?
The tea made from these leaves treats mouth ulcers and the discomfort generated by sore throat, laryngitis (inflammation of the larynx of vocal cord) and mouth swelling.

A topical application of their paste helps to heal wounds and various skin infections, like acne, due to their anti-bacterial nature. For this purpose, take around 10-15 leaves and chop them well. Pound or beat them gently using a bottle and then apply them on the affected parts and cover with a cloth. Leave it for around 24 hours and then change the poultice again till the wound heals completely.

Chewing guava leaves is considered as a fine weight loss remedy as they prevent starch from turning into sugar. The problems of high blood pressure and high bad cholesterol levels can also be controlled with the use of these leaves. For this purpose, just take some leaves and wash them in clean water and chop them and simply chew them. Chopping these leaves is essential as they are a bit hard, sometimes.
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Tuesday, 8 January 2013

Mouth

Source(google.com.pk)
Mouth Biography
Smash Mouth is an American rock band from San Jos?, California.

Formed in 1994, the band comprised Steve Harwell (lead vocals), Greg Camp (guitar), Paul De Lisle (bass), and Kevin Coleman (original drummer). Their hit songs include "Walkin' on the Sun" (1997) and "All Star" (1999).

Focused at times playing third wave ska music, the band has adopted retro styles spanning several decades of popular music, as well as performing covers of popular songs such as The Monkees' "I'm a Believer", War's "Why Can't We Be Friends" and The Beatles' "Getting Better". The band's 1999 release Astro Lounge is their most critically and commercially successful album to date.

History

Early years
In 1994 in San Jos?, California, Steve Harwell was a veteran of a disbanded rap group called F.O.S. which had released only one single, "Big Black Boots", available only on vinyl. His former manager was Kevin Coleman. Harwell wanted to form a rock band, so Coleman introduced him to friends guitarist Greg Camp and bassist Paul De Lisle, both veterans of a local punk band called Lackadaddy. They met and held their first rehearsal later, with Coleman on drums. They named themselves Smash Mouth after a football term coined by Chicago Bears coach Mike Ditka, describing a style of hard, straightforward and bare-knuckles rock-and-roll. For the most part, the band played ska punk, somewhat popular at the time, although Harwell has since claimed that the band is variously influenced.

Smash Mouth got its break in 1996 when San Jos? rock radio station KOME played a demo of the band's song "Nervous in the Alley" which achieved some notoriety. The group was signed by Interscope Records after a show, and Smash Mouth released a first album, Fush Yu Mang the next year, sporting a title in a font suggesting Oriental characters.

Fush Yu Mang
Fush Yu Mang is an intentional misspelling of "fuck you, man." The band explained in interviews that the name was inspired by watching an edited version of Scarface on TV. Fittingly, this is the only Smash Mouth album to be labeled by the Parental Advisory. "Walkin' on the Sun" was Smash Mouth's first major single, released in 1997. The opening riff and backbone of the tune is borrowed from the opening riff of "Swan's Splashdown", from the 1966 Perrey and Kingsley album The In Sound From Way Out! (considered to be the first-ever mainstream electronic music album). The lyrics in "Walkin' on the Sun" present an ironic and implied Generation X view of the hippie movement: that it extolled ideals of peace and love, then exchanged them for commerce. The song was the lead single from Fush Yu Mang. The album combined light-hearted fun with songs exposing a darker side, such as "Disconnect the Dots" and the aforementioned "Nervous in the Alley". "Let's Rock" did moderately well as the third and final single, and the album went double platinum.

Astro Lounge
Smash Mouth released their second album, Astro Lounge, in 1999. This album involved much less of the band's previous ska influence. It is more laid back, sophisticated and retro-sounding, and to a point, poppy. Although the change drove away some of the original fanbase, many new fans discovered Smash Mouth, and Astro Lounge is possibly the most critically acclaimed album from the group.

The Astro Lounge single "All Star" became popular in mid-1999, and it was featured on the soundtracks for the films Mystery Men and Inspector Gadget and later Shrek and Rat Race. "All Star" was followed by another single, "Then the Morning Comes". "Stoned" and "Waste" followed and did moderately well as singles. Astro Lounge was certified triple platinum. Kevin Coleman quit the band following the release of Astro Lounge due to lower back problems. He was replaced on tour by Mitch Marine (formerly with Tripping Daisy and Brave Combo) and later by Michael Urbano.

An instrumental cover of "Then the Morning Comes" by David Benoit subsequently became a hit on smooth jazz radio stations.

Smash Mouth
In 2001, Smash Mouth covered The Monkees hit "I'm a Believer". It was featured on the Shrek movie soundtrack as well as Smash Mouth's eponymous album Smash Mouth. However, as the song was released on the Shrek soundtrack first, it is believed many people purchased that album instead of Smash Mouth's own, contributing to poorer sales than their previous albums. Nonetheless, Smash Mouth had moderate success. With its singles "Holiday in My Head", "Pacific Coast Party", and "Shoes n' Hats" to support it, along with "Forcefield", the album was certified Gold.

Get the Picture?
Get the Picture? was the next Smash Mouth album, released in 2003. The album sold a disappointing 33,000 units, especially compared to the way Smash Mouth has sold in the past. A moderately popular single, "You Are My Number One" attracted some attention, while the singles "Hang On" from The Cat in the Hat (film) and "Always Gets Her Way" flopped. Due to the low sales as well as the band's concerns of loss of creative control, Smash Mouth was dropped from Interscope. 2003 also saw the release of the animated film The Jungle Book 2 which features the band on the soundtrack singing the Sherman Brothers song "I Wanna Be Like You".

Following Get the Picture?s run the band very much fell out of the public eye that they had been in for the past few years. As a few years went by the bands whereabouts were very much unknown to the public, with the only hints of their existence being a few songs recorded for movie soundtracks by Steve Harwell only, leading many to believe that Smash Mouth had broken up and Harwell had gone solo.

Following their signing to Universal Records, Smash Mouth released a greatest hits compilation All Star Smash Hits in 2005. The album contains some of the more popular songs from previous Smash Mouth albums, as well as songs from soundtrack albums which were not on the band's own releases. On certain networks and timeslots, the album was advertised as having 18 tracks, including Flo and Beer Goggles. Smash Mouth played at Gumby's Birthday Celebration in August 2005.

Gift of Rock
In December 2005, the band released a Christmas album Gift of Rock. It featured covers of Christmas songs by many artists, such as The Kinks and The Ramones, and one original song, "Baggage Claim".

Hiatus, Old Habits
Smash Mouth's fifth studio album, Old Habits, was expected to be released in early 2006. The band had said that the album was much more like the Ska Punk featured on Fush Yu Mang and The East Bay Sessions. In September 2005, the band performed what was tentatively going to be the album's first single, "Getaway Car", on Last Call with Carson Daly. The album was delayed many times, in the hope of gaining publicity with Steve's appearance on the reality show The Surreal Life. Smash Mouth returned to the studio intent on making their new record better. Old Habits was shelved, replaced by Summer Girl, which included some remixed Old Habits tracks as well as new songs. After being delayed in much the same way Old Habits was for several months, the album was released on , 2006. Smash Mouth let Sony Pictures use much of their music from Summer Girl and other songs for the movie Zoom, whose opening titles credit the film's music to the band.

Summer Girl and Future
Before the release of Summer Girl, the Smash Mouth community was surprised when drummer Michael Urbano left the band without warning on , 2006 due to creative differences. The band found a new drummer, Jason Sutter, best known for his work with American Hi-Fi and The Rembrandts. The band released their new album, Summer Girl later that year. In early 2007, just one year after joining the band, Jason Sutter left Smash Mouth to play drums for former Soundgarden and Audioslave front man, Chris Cornell. Fill-in drummer Mitch Marine returned to Smash Mouth and had said that this time he would be a permanent member. However he was replaced in June 2009 when Michael Urbano returned.

The band is currently back in the recording studio, and according to Smash Mouth's MySpace blog, a new album was to be out sometime in early 2009. The group recently appeared on the 2009 Darryl Worley album entitled Sounds Like Life on the track "Don't Show Up (If You Can't Get Down)".

In the summer of 2008, Greg Camp left the band and released his solo album Defektor. Smash Mouth recruited Leroy Miller to play guitar. In the summer of 2009 Camp officially rejoined the band with former drummer Michael Urbano. According to a response to fan mail, the style of their next album will be close to that of Smash Mouth's earlier albums, Fush Yu Mang and Astro Lounge.
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Oral Cancer

Source(google.com.pk)
Oral Cancer Biography
The gentle touch of a brush on the tongue or cheek can help detect oral cancer with success rates comparable to more invasive techniques like biopsies, according to preliminary studies by researchers at Rice University, the University of Texas Health Science Centers at Houston and San Antonio and the University of Texas M.D. Anderson Cancer Center. A new test that uses Rice's diagnostic nano-bio-chip was found to be 97 percent "sensitive" and 93 percent specific in detecting which patients had malignant or premalignant lesions, results that compared well with traditional tests.

The results of this study, which was led by John McDevitt, were published in the journal Cancer Prevention Research. Oral cancer afflicts more than 300,000 people a year, including 35,000 in the United States alone. The five-year survival rate is 60 percent, but if oral cancer is detected early, that rate rises to 90 percent.

"One of the key discoveries in this paper is to show that the miniaturized, noninvasive approach produces about the same result as the pathologists do," said Dr. McDevitt, whose group developed the novel nano-bio-chip technology.

Dr. McDevitt and his team are working to create an inexpensive chip that can differentiate premalignant lesions from the 95 percent of lesions that will not become cancerous. The minimally invasive technique would deliver results in 15 minutes instead of several days, as lab-based diagnostics do now. Instead of an invasive, painful biopsy, the new procedure requires just a light brush of the lesion on the cheek or tongue with an instrument that looks like a toothbrush.

"This area of diagnostics and testing has been terribly challenging for the scientific and clinical community," said McDevitt, who came to Rice from the University of Texas at Austin in 2009. "Part of the problem is that there are no good tools currently available that work in a reliable way."

He said patients with suspicious lesions, which are usually discovered by dentists or oral surgeons, end up getting scalpel or punch biopsies as often as every six months. "People trained in this area don't have any trouble finding lesions," McDevitt said. "The issue is the next step — taking a chunk of someone's cheek. The heart of this paper is developing a more humane and less painful way to do that diagnosis, and our technique has shown remarkable success in early trials."

Nano-bio-chips are small, semiconductor-based devices that combine the ability to capture, stain and analyze biomarkers for a variety of diseases. Researchers hope the eventual deployment of nano-bio-chips will dramatically cut the cost of medical diagnostics and contribute significantly to the task of bringing quality health care to the world.

The new study compared results of traditional diagnostic tests with those obtained with nano-bio-chips on a small sample of 52 participants. All of the patients had visible oral lesions of leukoplakia or erythroplakia and had been referred to specialists for surgical biopsies or removal of the lesions.

The chips should also be able to see when an abnormality turns precancerous. "You want to catch it early on, as it's transforming from pre-cancer to the earliest stages of cancer, and get it in stage one. Then the five-year survival rate is very high," he said. "Currently, most of the time, it's captured in stage three, when the survivability is very low." The device is on the verge of entering a more extensive trial that will involve 500 patients in Houston, San Antonio and England.

This work is detailed in a paper titled, “Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology.” An abstract of this paper is available at the journal’s Web site.
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