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Friday, 29 March 2013

United Cancer Research

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United Cancer Research
The Latest Expansion in Mesothelioma Research in United StatesOncological journals have recorded that researchers have found two drugs used in combination while their mesothelioma cancer research Tomudex and Platinol have increased the lifespan of mesothelioma cancer sufferers. The combination of the two bought about a good result which was much better than the use of Platinol by itself. Researchers have known for some time that the use of two chemicals on an organism often made the effect of each other more powerful than used individually. Using one chemical increases the effects of the next. Researchers call this the synergistic effect. The research helped a few mesothelioma cancer victims overcome a particular crisis usually associated with Mesothelioma patients, like:
fatigue
loss of appetite
cough
pain
shortness of breath
Ongoing ResearchUnited States research on mesothelioma treatments is increasing with American scientists working on various ways to bring relief to those with the deadly cancer. Scientists in the United States are striving to increase the value of information gathered on the illness and gaining knowledge of the healing possibility of many herbs and roots. However most of those researching mesothelioma cancer are focused on understanding the way asbestos in the body can affect cells and the DNA of cells making them cancerous. Learning what makes these asbestos fibers produce cancerous cells will assist in creating ways to avert these mutations.On Going Quest to Solve the Mysteries of Asbestos CancerThe risk of asbestos exposure turning into mesothelioma cancer is definitely a concern in the United States. Researchers are always looking at studying different types of asbestos fibers that develop into cancer. They are looking into how the fibers cause mesothelioma cancers and when the ingestion of asbestos is the most dangerous. Even municipalities and non-government agencies are trying to lower the problems with asbestos exposure. The research into safeguarding the health of U.S. citizens from the dangers asbestos exposure is taken very seriously by scientist and there is also research into possible other causes of mesothelioma cancer. The latest Mesothelioma cancer research in the United States is ever evolving to find solutions to prevention, diagnosis, treatments and eventually a cure to the deadly cancer. This entry was posted on Wednesday, July 28th, 2010 at 4:55 am and is filed under Mesothelioma News . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
United Cancer Research
United Cancer Research
United Cancer Research
United Cancer Research
United Cancer Research
United Cancer Research
United Cancer Research

United Cancer Research
United Cancer Research

Facts On Cancer

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Facts On Cancer

1.Cancer occurs when cells in a part of the body begin to grow out of control. They continue to grow and crowd out normal cells. Although there are many kinds of cancer, they all have this out-of-control growth of cells in common.
2.Cancer causes more deaths every year than deaths caused by AIDS, tuberculosis, and malaria combined.
3.The World Health Organization (WHO) estimated that in 2010, 569,490 died from cancer in the United States.
4.WHO estimates that about 40% of all cancers are preventable by maintaining a healthy diet, exercising, and not using tobacco.
5.Leukemia cancers make up 25% of all childhood cancers, affecting around 2,200 in the United States each year.
6.It is estimated that nine million people will die from cancer in 2015, and 11.4 million will die in 2030, showing an expected increase in number of people with cancer.
7.Not using tobacco is the best way to prevent certain cancers such as lung, throat, mouth, pancreas, bladder, stomach, liver, and kidney.
8.Second hand smoke can cause lung cancer.
9.About 75% of cancer cases are caused by environmental factors such as radiation, tobacco, diet, and infectious diseases.
10.One new case of prostate cancer arises every two and a half minutes. Every 17 minutes, a man dies from prostate cancer.
11.Lung cancer is the most fatal of all the cancers, followed by prostate cancer.
12.Save a life today. It's as easy as getting your cheek swabbed! GO

Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer
Facts On Cancer

Monday, 11 March 2013

What Is Myeloma

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What Is Myeloma Biography

Years ago, when I was working as an undergraduate in a research laboratory of one of the top-ranked medical schools in the United States, I was fascinated with all things related to cancer research – especially cancer treatment. Multiple myeloma was one of the malignancies that I was hoping to combat in my future career as a researcher. I specifically recall one afternoon when I told my PI that I was going to be the one to “finish off” multiple myeloma, to which he responded something along the lines of “I’m sure you will – but first you ought to finish the PCR.” The PCR (Polymerase Chain Reaction) kept me in the lab, by myself, until 11:30 on a Friday night.
Events like that helped me change my mind about my career path, although the interest in cancer (and multiple myeloma) never really left. That is why I’ve decided to dedicate an article specifically to our most recent advances in multiple myeloma treatment and the investment applications.

2012′s New Proteasome Inhibitor – Kyprolis (carfilzomib)

The multiple myeloma world was shaken last year after the FDA approval of Onyx Pharmaceuticals’ (ONXX) proteasome inhibitor Kyprolis/carfilzomib on July 20th, 2012. The approval seemed to surprise Wall Street to some extent, resulting in an immediate 10% rally in the stock and a subsequent rally all the way to the 52-week high of $93.18/share in mid-October.

It was clear that the FDA’s accelerated approval of Kyprolis/carfilzomib based on just the phase IIb 003-A1 study was enough to convince a good number of skeptics that this was the wrong drug to bet against. About 1 million shorted shares were covered in the weeks following the FDA approval, and the stock rebounded terrifically from the “sell the news” reaction that caused drops in August 2012. While volume seems to be drying up for ONXX, many investors still remain optimistic on Kyprolis as we head into a new year.

On January 15th, 2013 Onyx did announce a public offering of 4.4 million shares of common stock (diluting shares by about 6.5%, not including another 660,000 shares granted to cover potential overallotments), although I think that this move was unsurprising and necessary for Onyxx to raise the funds needed to effectively market Kyprolis and simultaneously improve second-line myeloma treatment in the United States.

It’s also worth noting that Kyprolis is not the first proteasome inhibitor that was approved for multiple myeloma treatment. That honor belongs to Velcade (bortezomid), which was created by Millenium Pharmaceuticals – now a subsidiary of Takeda Pharmaceuticals (TKPYY). While drugs that have a similar mechanism of action often have to compete directly with one another, Kyprolis can actually extend the lives of patients who have already taken bortezomid, and hence captures a niche market for itself while offering a second chance to myeloma patients who don’t respond to current standard-of-care drugs.

Onyx is trading at $83.43/share, and with a market capitalization of $5.6 billion. It isn’t a cheap play anymore, but their other cancer drug Nexavar (sorafenib) is expected to continue sales growth to make up for the fact.

Takeda is trading at $24.67/share, and has an approximate market cap of $39 billion. It is not traded on either of the two major U.S. exchanges, so note that liquidity is lower and volatility is generally higher. I think that this can make the stock harder to trade in the short term, but shouldn’t necessarily discourage investors who believe in the company and its prospects.

Some Upcoming Myeloma Drugs

There is no feasible method to adequately cover all of the myeloma drugs in development right now with a single article, but we can at least glance at a few treatments that have caught my recent attention.

1.) Elotuzumab (HuLuc63) – the humanaized monoclonal antibody in phase III trials developed by big pharma name Bristol-Myers Squibb (BMY)

I briefly mentioned elotuzumab in a recent article I wrote on Senesco Technologies (which is also mentioned in this article) although I didn’t elaborate on the drug very much. I think investors should be interested in monoclonal antibody-based cancer therapies (it’s the next big thing), especially for myeloma due to the difficulty in targeting the malignant plasma cells.

Antibody therapies like elotuzumab have shown terrific results in the slowing of malignancies (as measured through progression-free survival). Phase IIb trial results presented at the American Society of Hematology (ASH) meeting on December 9, 2012. If granted approval, elotuzumab would become another name on a growing list of treatments for patients when they require second-line treatment of myeloma. The results are available on the Bristol-Myers website, although the general implications of the recent clinical trial data are summarized well by company statements.

“The Phase 2 PFS data for elotuzumab presented today are encouraging and support further evaluation of this antibody in patients with multiple myeloma as part of large Phase 3 trials.”

Dr. Paul Richardson, Clinical Director, Jerome Lipper Center for Multiple Myeloma

BMY is trading at a price of $34.30/share, and a market capitalization of $57 billion. It is the only stock mentioned in this article that offers a dividend, which works out to be a 4.10% yield. Due to its sheer size, I wouldn’t expect elotuzumab to significantly affect the stock even under optimistic conditions, but it certainly won’t hurt the company if it ends up successful.

2.) Ibrutinib (PCI-32765) – the Bruton’s tyrosine kinase inhibitor for blood cancers by Pharmacyclics (PCYC)

Bruton’s tyrosine kinase (BTK) is a very mysterious enzyme that is still not fully understood, but its malfunctioning has been associated with blood-based cancers. This is specifically related to the pathway of a particular receptor called B-cell receptor, which is associated with the proliferation of B-cells. Given that we are right about these associations, BTK (which means BCR) is a good potential angle to target abnormal cell proliferation in B-cell malignancies. Pharmacyclics intends to try its BTK inhibitor Ibrutinib against the most prevalent B-cell malignancies – which includes multiple myeloma.

Pharmacyclics has made the most progress with its CLL (Chronic Lymphocytic Leukemia) indication. This particular program is moving into phase III trials. Multiple Myeloma is the laggard of the group, although I think that this program has big potential due to the unique mechanism of action. The company should be able to skip phase I development for this indication, which now leaves the phase II testing of the drug’s actual efficacy in myeloma. Since we saw good data for CLL and other B-cell malignancies, I don’t see why the development program for myeloma shouldn’t be drawing interest.

Pharmacyclics has been doing well in recent trading, now trading at $66.96/share and a market cap of $4.76 billion. All the positive developments in the company have tripled the stock in the last year, which makes it a bit more expensive but does increase the safety of the stock to some degree. Investors are generally optimistic about ibrutinib.

3.) SNS01-T – leading the attack on a new potential oncogene, Senesco Technologies (SNTI)

Senesco is an undiscovered name that caught my attention for two big reasons. One was the fact that Harlan Waksal was chairman of the board at the company (he is famous for creating ImClone – now a subsidy of Eli Lilly), as well as Christopher Forbes (of the Forbes family). CEO Dr. Leslie Brown also has a great track record.

The second was the fact that the company was brand new – at least in the sense that it only became a biopharmaceutical company a few years ago (2009). On top of that, the company had a very unique angle for the treatment of multiple myeloma. The eIF5A gene affects proteins that are integral to the process of apoptosis (programmed cell death). Malignant cells can replicate infinitely because of the destruction of the apoptosis pathway, which is made by nature to destroy cells that have “flaws” (like every cancer does). I think that eIF5A could be an extremely interesting target for all cancer types, although I don’t think multiple myeloma was a bad first choice. Note that Senesco also intends to expand SNS01-T’s indication to mantle cell lymphoma and other B-cell malignancies, along with myeloma.

Senesco is trading at $.13/share, and has a very low market capitalization of $15.2 million. Like Takeda, it is traded on the OTC market. The company’s small size adds significantly to the volatility of the company, although I think that further developments for SNS01-T (now in phase Ib/IIa trials) could garner some new investor interest in the radically different therapy being developed by them. I also think the stock could see a return to the NYSE or NASDAQ in the future (it was on the NYSE but was controversially delisted in 2012). Note that Senesco is the most risky investment mentioned in this article due to the volatility of the stock and the small size of the company.

Conclusion

As stated before, there are many more drugs in development that I wish I could cover. This article offers only a taste of the developments being made in multiple myeloma, and I think that there is a substantial amount of money to be made as well. Also note that there is substantial variety – huge and small companies alike are looking for new ways to treat myeloma patients.

There are also few investments out there that can offer investors enormous ROI as well as knowledge that they are benefiting the welfare of patients all around the world. That has to count for something, right?

Monday, 4 March 2013

Health Cancer

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Health Cancer
  Can backtrack Although there is no guarantee that you will not be contracted, most cancers in your life, there are some tips on healthy living at risk. Scientists now believe that one-third of cancer through proper nutrition, a program to train daily and maintain a healthy body weight could be avoided. These are three things to do on the long approach to reduce the risk. The analysis showed that live on even small adjustments in your way is a big difference in quality of life for many years and decades to do. Thus, we can access some of the things we do not seek the.

It is believed that maintaining a healthy weight important factor for you to do, not to smoke in the harbor. It is controlled so that the index of the individual body mass (BMI) trying to keep down the end of their range. The data indicate that the extra fat is a risk to issue as many as six different types of cancer. It would be most cancers: colon, presenting menopause, breast cancer the most, most esophageal cancers, renal cancers, most, most pancreatic cancer and endometrial cancer. Body fat may begin with an increased risk for most cancers, gallbladder and be linked.

We all know that the program regular train just is not only good for heart health but overall health in general. It may perhaps also at the rear of the risk of many cancers. The added benefit here is that it will also allow you to manage weight. It is confirmed that you are currently not less than half an hour a day and improved to ensure better on at least an hour, your fitness level. Take a few minutes to think about what you like, if you do not currently have a training program. This allows you to continue the program for the long term.

Diet is essential for most types of cancer to reduce your risk. Limit or avoid foods that can never fat and sugar in a small amount of fiber. These are the types of foods that can cause us to be chubby and overweight, this is probably one of the factors most important risk for cancer is growing. Stay away from fast foods and processed as much as you can. Stir in fresh fruits, whole grains, vegetables and beans in your diet as much as possible. Try these five servings of vegetables-based diet usually eat each day. The plans, which include an excessive amount of disk excess of high fiber foods back the risk of most cancers, and therefore a healthy weight.



Cancer And Health

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Cancer And Health
Many population groups across the United States and around the world suffer disproportionately from cancer and its after-effects. Overcoming cancer health disparities is one of the best opportunities we have for lessening the burden of cancer. NCI supports research to identify and understand the factors that contribute to disparities. NCI also funds studies to develop and disseminate culturally appropriate interventions.

The Center to Reduce Cancer Health Disparities is the cornerstone of the NCI's efforts to reduce the unequal burden of cancer in our society. The Center is committed to improving our understanding of the causes of disparities and reducing and eliminating them.









Friday, 1 March 2013

Alternative Cancer Treatment Centers

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Alternative Cancer Treatment Centers Biography
Complementary and Alternative Medicine
A guide to help you navigate the realm of complementary and alternative medicine with tips and warnings on treatments such as herbals, vitamins, chemicals, diet, meditation, massage, acupuncture, and body-mind therapy.

Gene Therapy
Find out how researchers are trying to use this cutting edge therapy in an attempt to boost the immune system and improve the body's natural ability to fight cancer.

Hormone Therapy
Support and information about the various hormonal therapies used to treat several types of cancer, including breast and prostate cancer.

Procedures & Diagnostic Tests
Articles explaining the many tests used to diagnose and monitor cancer, including radiology tests, various types of biopsies, tests to evaluate the gastrointestinal track, tumor markers and more.

Proton Therapy
Proton therapy is an advanced form of radiation therapy currently in use at a limited number of centers worldwide. Includes the OncoLink/EmergingMed Proton Trial Matching Service, which assists patients in finding proton therapy trials.

Radiation
Information about radiation therapy and treatment side effects. Includes information on Photodynamic Therapy (PDT).

Surgery
Support and information about the various surgical procedures used to treat many types of cancer.

Targeted Therapies
This multi-part educational section describes the science behind targeted therapies and reviews the major classes of targeted therapies. This section will only discuss approved therapies.

Vaccine Therapies
One of the more complex topics in cancer treatment and one of the most rapidly changing fields of cancer research.
Alternative Cancer Treatment Centers
Alternative Cancer Treatment Centers
Alternative Cancer Treatment Centers
Alternative Cancer Treatment Centers
Alternative Cancer Treatment Centers
Alternative Cancer Treatment Centers

New Cancer Treatment

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New Cancer Treatment

Hope Hospitals use the newest neurological approaches to provide effective and safe stem cell treatments to a wide range of neurological disorders as well as Cancer and other diseases.

We use the latest knowledge of stem cell behavior in the human body within an individually tailored medical plan according to the patient’s condition. Using stem cell transplantation, intensive physiotherapy and medicines, this combination of therapies has so far proved itself to be most efficient in bringing high level of recovery to our patients
Most cells in the body have a specific function in particular organs, such as the liver, skin or brain. Stem cells are relatively undifferentiated and still have the ability to develop into different types of cells to exert different functions.
A stem cell's most notable characteristic is its ability to reproduce a completely new, normal, and even younger cell. As a result, people can use their own or someone else’s stem cells, or stem cell -derived tissues or organs, to replace ill or aging tissues or organs. This permits treatment of a wide range of diseases and injuries, many of which cannot be treated with traditional medical methods.
CIK IMMUNOTHERAPY FOR CANCER    

"Instead of using surgery, chemotherapy, or radiotherapy, researchers from the National Institutes of Health are finding so-far limited but inspiring success in a new approach for fighting cancer, using the immune system to attack the tumors the way it would be a cold or flu."   - CNN.com (August 2006)
CIK has proved in medical practice to be the most efficiently adopted immunotherapy.  It shows good efficacies in treating malignant tumors in leukemia, melanoma, malignant lymphoma, renal cell carcinoma, metastatic renal carcinoma, lung cancer, liver cancer, breast cancer, ovarian cancer, colon cancer, and gastric cancer.

This treatment can be applied to cancer patients in any stage, and it has good short-term effects for both early stage patients and advanced stage ones. CIK cells eliminate small lesions not available for surgery and tiny cancerous cells scattered in the body to delay or prevent the metastasis or recurrence of tumor. It will have a better efficacy when combined with surgical resection, intervention, radiofrequency therapy, or cryoablation. 






Alternative Cancer Treatment

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Alternative Cancer Treatment
Cancer is considered to be one of the most dreadful diseases. Unfortunately, there is no specific treatment to eradicate it from its roots. Various researchers associated with cancer research are still trying to find a definite cure for this shape shifting disease. Although, conventional treatments are available for cancer, but patients in the initial stages of the diseases are advised to follow some alternative therapies which have proved promising in treating cancer and dealing with some of its effects on the body. Below we discuss some of these treatments.

Acupuncture as alternative cancer treatment
This is one of the most popular alternative treatments for cancer. In this therapy, small pins or sterile needles are inserted in some definite points into the skin. It is a very relaxing technique, helps in removing nausea that resulted after chemotherapy treatment, and at the same time is helpful in releasing cancer-related pains. Cancer patients should not undergo this treatment if their blood count is not at optimum levels or if they are on any blood thinning medications currently. Consult your doctor before embarking upon this alternative therapy. While choosing the above, make sure that you put your body in the hands of a licensed and experienced acupuncture therapist.

Aromatherapy for cancer treatment

Oil mixed with fragrances, such as lavender, rose, etc., can be extremely successful in promoting a calm and relaxed feeling in cancer patients. In this therapy, scented oils are either heated to release the fragrance in the atmosphere or mixed with the bath water. The perfect choice is always to have a massage with scented oil. Aromatherapy helps in releasing pain, stress, and nausea sensations. However, at times these oils may cause a skin allergy in some patients. Hence, keep this in your mind before going committing to this treatment. Make sure that you put your body under the ministrations of an experienced aromatherapy massage practitioner and consult him on the best therapy for your particular symptoms and condition.



Biofeedback for cancer treatment
This treatment involves training your mind to monitor various functions of the body, such as heart rate, blood flow rate, muscle relaxation process, etc which normally take place involuntarily. In this process, a biofeedback therapist connects the electronic device to your body at certain specific points to monitor specific body functions. The device produces a beeping sound or has a light indicator to signal any extraordinary physiological activity. Once you have identified the problem area, for example high blood pressure or extreme sensation of pain, the therapist works with the patient to control this response. With the help of meditation and other mental exercise, the patient would be able to control body processes which are usually involuntary. The biofeedback monitor helps chart the progress of the patient and these tangible readings act as a motivating factor in continuing with the therapy. Biofeedback is especially helpful in controlling pain responses, blood pressure problems and incontinence in a cancer patient.

Treatments On Cancer

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Treatments On Cancer
Information about cancer treatment, including surgery, chemotherapy, radiation therapy, clinical trials, proton therapy, complementary medicine, and cutting edge technologies.

Biologic Therapy
Biologic therapies work by helping the immune system to function better by using substances that occur naturally in your body to fight cancer. Biologic therapies include Gene Therapy and Vaccine Therapies.

Bone Marrow Transplants
Support and information for bone marrow, peripheral blood stem cell, and cord blood transplants.

Chemotherapy
Information about chemotherapy treatment, drugs and side effects. Includes an overview of the treatment process and OncoLink Rx, a list of teaching sheets about chemotherapy drugs.

Clinical Trials
Tools to help empower cancer patients to evaluate research studies for which they may be eligible. Includes the OncoLink/EmergingMed Clinical Trials Matching Service, which encourages patients to seek out and consider clinical trials for the treatment of their cancer.
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer
Treatments On Cancer